Development of a dose-response bioassay for stanniocalcin in fish

Lay Summary

I co-wrote an article that explores the development of a new method to test how fish respond to a hormone called stanniocalcin (STC). This hormone is important for managing calcium and phosphate in the body, which is crucial for healthy bones and other bodily functions. Previously, scientists didn’t have a reliable way to measure the effects of STC in fish, which limited understanding of its role. This study introduced a technique that involves adjusting the levels of phosphate in rainbow trout, which made them more responsive to STC. This allows researchers to accurately measure how different doses of STC affect the transport of calcium in fish gills. This breakthrough provides a valuable tool for further study of STC, not just in fish but potentially in mammals too, helping scientists understand more about how this hormone works across different species.

Reference

Wagner, G. F., De Niu, P., Jaworski, E., Radman, D., & Chiarot, C. (1997). Development of a dose-response bioassay for stanniocalcin in fish. Molecular and cellular endocrinology, 128(1-2), 19-28.

DOI: https://doi.org/10.1016/S0303-7207(97)04009-4